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Efficacy of Combination Therapy of Mefenamic acid and Tranexamic Acid in Heavy Menstrual Bleeding

Dysfunctional uterine bleeding is excessive, prolonged heavy or frequent bleeding of uterine origin which is not due to pregnancy or any systemic or recognizable pelvic disease.

Assessment and Management of Heavy Menstrual Bleeding

Heavy menstrual bleeding (HMB), a prevalent and distressing condition, is primarily defined by the patient's perception and observable signs like frequent pad or tampon changes, large clots, and disruption of daily activities.

These clinical practice guidelines intend to provide the practicing psychiatrists a ready reckoner to identify Heavy Menstrual bleeding, assess them, treat and manage side effects of medications among elder individuals.

Bitzer J, Heikinheimo O, Nelson AL, Calaf-Alsina J, Fraser IS. Medical management of heavy menstrual bleeding: a comprehensive review of the literature. Obstetrical & gynecological survey. 2015 Feb 1;70(2):115-30.

Ref:Naoulou B, Tsai MC. Efficacy of tranexamic acid in the treatment of idiopathic and non-functional heavy menstrual bleeding: a systematic review. Acta Obstet Gynecol Scand 2012; 91:529–537.

Madhu J, Shylaja AS. Randomised trial of mefenamic acid versus tranexamic acid in management of menorrhagia. Int J Reprod Contracept Obstet Gynecol 2017;6:4608-12.

Guidelines

Total Question : 9

Case Studies

Combination therapy with Mefenamic acid and Tranexamic acid in heavy menstrual bleeding: An Interesting Case Report.

A 32-year-old female patient presented with chief complaints of heavy and prolonged menstrual bleeding for the last 7–8 months.
Last menstrual period persisted for seven days and needed a change of six pads per day.
No intermenstrual spotting.
No history of vaginal white discharge, backache, weight loss/gain, dyspareunia, or any urinary complaints.
No known medical comorbidities.

Efficacy of Mefenamic acid and Tranexamic acid in Management of Heavy Menstrual Bleeding: A Case Report

A 40-year-old female patient with complaint of heavy menstrual bleeding.
No history of renal or hepatic impairment
No coagulation or fibrinolytic disorder.
No previous history of thromboembolism, peptic ulceration and inflammatory bowel disease.

Recent Updates on Prevalence and Burden of Heavy Menstrual Bleeding in Society.

Heavy menstrual bleeding is a common disorder characterized by excessive blood loss that affects the quality of life of a female in physical, emotional, social and financial aspects.

Heavy menstrual bleeding might be caused due to polyps, fibroids, adenomyosis, irregular ovulation, bleeding disorders, drugs, cancer and other etiologic factors. Physical health problems like iron deficiency anemia and fatigue may also be due to heavy bleeding in menstrual period in some cases.

Heavy Menstrual Bleeding and Anemia: Heavy Menstrual bleeding can cause decrease in the amount of hemoglobin and iron level and lead to anemia if not treated. Of all the women having heavy menstrual bleeding 2/3rd of the women suffered from Anemia.

The ICMR recommendations on the management of heavy menstrual bleeding

It is crucial to obtain a medical history for complete understanding of the current bleeding episode.

History taking should include:

Age
Number of pregnancies
Thorough menstrual history, including irregularities.
Other medical conditions: thyroid disorder, jaundice, coagulopathy, etc.
Intrauterine contraceptive device (IUCD) use
Medication use
Lactation

Texakind-MF

Texakind-MF Tablet is a combination medicine used to treat dysmenorrhea (period pain) and menorrhagia (heavy menstrual bleeding). Besides this, Texakind-MF Tablet is also used to treat severe blood loss, swelling in various body parts, fever, inflammation, and migraine headache. Menstrual cramps, also known as dysmenorrhea, are characterized by cramps and pain during menstruation. Menorrhagia is a condition with abnormally heavy or prolonged bleeding during menstruation/periods.

Texakind-MF Tablet is a combination of two drugs: Tranexamic acid (anti-fibrinolytic) and Mefenamic acid (NSAID). Tranexamic acid helps the body's natural blood clot process by preventing fibrin's breakdown, this stops fibrinolysis, a process that stops blood clot formation. Mefenamic acid works by blocking the effect of chemical messengers that cause pain.